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KMID : 0043320080310040415
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Archives of Pharmacal Research
2008 Volume.31 No. 4 p.415 ~ p.418
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Cytotoxic Components from the Dried Rhizomes of Zingiber officinale Roscoe
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Kim Ju-Sin
Lee Sa-Im
Park Hye-Won
Yang Jae-Heon
Shin Tae-Yong
Kim Youn-Chul
Baek Nam-In
Kim Sung-Hoon
Choi Sang-Un
Kwon Byoung-Mog
Leem Kang-Hyun
Jung Mun-Yhung
Kim Dae-Keun
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Abstract
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Five compounds were isolated from the chloroform-soluble fraction of the methanolic extract of the dried rhizomes of Zingiber officinale (Zingiberaceae) through repeated column chromatography. Their chemical structures were elucidated as 4-, 6-, 8-, and 10-gingerols, and 6-shogaol using spectroscopic analysis. Among the five isolated compounds, 6-shogaol exhibited the most potent cytotoxicity against human A549, SK-OV-3, SK-MEL-2, and HCT15 tumor cells. 6-shogaol inhibited proliferation of the transgenic mouse ovarian cancer cell lines, C1 (genotype: , c-myc, K-ras) and C2 (genotype: , c-myc, Akt), with values of 0.58 (C1) and 10.7 (C2).
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KEYWORD
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Zingiber officinale, Zingiberaceae, Gingerol, Shogaol, Cytotoxicity, Cell proliferation
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